In late 1999, Erik Davis conducted what would be the last interview with McKenna. During the interview McKenna also talked about the announcement of his death:
I always thought death would come on the freeway in a few horrifying moments, so you’d have no time to sort it out. Having months and months to look at it and think about it and talk to people and hear what they have to say, it’s a kind of blessing. It’s certainly an opportunity to grow up and get a grip and sort it all out. Just being told by an unsmiling guy in a white coat that you’re going to be dead in four months definitely turns on the lights. … It makes life rich and poignant. When it first happened, and I got these diagnoses, I could see the light of eternity, a la William Blake, shining through every leaf. I mean, a bug walking across the ground moved me to tears.
McKenna died on April 3, 2000, at the age of 53.